文章基本信息

标题：Effects of Oral Administration of Vitamin D3 Metabolites on Histological Changes of Intestinal Mucosa
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作者：Masami INADA ; Shigeya WATANABE ; Yoshio WAKATSUKI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：3
期号：3
页码：201-207
DOI：10.3164/jcbn.3.201
出版社：The Society for Free Radical Research Japan
摘要：Effect of administration of active vitamin D₃ on the histological changes of intestinal mucosa was studied in normal rats treated with 0.25 to 0.5μg of 1α(OH)D₃ or 1α, 25(OH)₂D₃. Mucosal thickness, cell count and volume, mucosal mass, and nuclear size were morpho-metrically measured in the villi and crypts. In the villi, both 1α(OH)D₃ and 1α, 25(OH)₂D₃ significantly increased the cell counts, moderately increased the thickness, and slightly increased the cell volume, compared with the control group. Neither agent had any effect on the crypts. Nuclear size in villi was increased only in the 1α, 25(OH)₂D₃ group.
关键词：1α(OH)D3;1α,25(OH)2D3;cell differentiation;villi;crypts