文章基本信息

标题：Effect of Diallyl Sulphide, Diallyl Disulphide, and Allyl Methyl Sulphide on the Inhibition of Lung Metastasis of B16F-10 Melanoma Cells in Mice
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作者：Girija KUTTAN ; Ramadasan KUTTAN
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1999
卷号：27
期号：3
页码：131-139
DOI：10.3164/jcbn.27.131
出版社：The Society for Free Radical Research Japan
摘要：Effect of naturally occurring sulphur-containing compounds such as diallyl sulphide (DAS), diallyl disulphide (DADS), and allyl methyl sulphide (AMS) on the inhibition of lung metastasis of B16F-10 melanoma cells was studied in C57BL/6 mice. Simultaneous administration of the compounds after tumor induction produced a significant reduction in tumor nodule formation (DAS 55%, DADS 90%, and AMS 54%). The effect was lower when the compounds were administered after tumor development, whereas prophylactic administration of the compounds did not have any effect on lung tumor nodule formation. Increased lung collagen hydroxyproline, serum sialic acid, and gamma glutamyl transpeptidase activity in the metastasized lungs of control animals was significantly reduced in the animals treated with the sulphur-containing compounds. Pathology of the lung tissue also correlated with the above findings. Our results are indicative of the antimetastatic activity of these sulphur-containing compounds.
关键词：diallyl sulphide;diallyl disulphide;allyl methyl sulphide;metastasis;melanoma