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标题：Coenzyme Q10 and Its Role in Heart Disease
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作者：Ram B. SINGH ; Mohammad A. NIAZ ; Shanti S. RASTOGI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1999
卷号：26
期号：2
页码：109-118
DOI：10.3164/jcbn.26.109
出版社：The Society for Free Radical Research Japan
摘要：Coenzyme Q₁₀ (CoQ₁₀) deficiency has been observed in apparently healthy subjects as well as in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse and after coronary revascularization. CoQ₁₀ bolsters the synthesis of ATP and inhibits free radical damage, hence is useful in preventing cellular damage during ischaemia-reperfusion injury. The clinical benefits are mainly due to its ability to improve energy production, antioxidant activity, and membrane stabilizing properties. Several small scale studies indicate that coenzyme Q could be useful in patients with congestive heart failure, angina pectoris, cardiomyopathy, coronary artery disease, acute myocardial infarction and in the preservation of myocardium. CoQ₁₀ may also decrease lipoprotein (a) and plasma insulin. CoQ₁₀ is normally present in the low-density lipoprotein cholesterol fraction and inhibits its oxidation indicating that it can inhibit atherosclerosis. It can also regenerate vitamin E. CoQ₁₀ is known for producing minor gastrointestinal discomfort and elevation in SGOT and LDH when used.
关键词：ubiquinone;coronary artery disease;hypertension;heart failure;cardiomyopathy;myocardial infarction