文章基本信息

标题：The Role of Ascorbic Acid in the Mosaic of Coronary Heart Disease
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作者：Cheryl L. ALWAN ; Andrew J. BROWN ; Vicki A. COOPER 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1999
卷号：26
期号：2
页码：85-98
DOI：10.3164/jcbn.26.85
出版社：The Society for Free Radical Research Japan
摘要：Ascorbic acid (AA) is purported to have a preventative role in coronary heart disease (CHD) incidence. Studies in animal models support an interaction of AA in lipid metabolism, while results from epidemiological and supplementation trials conducted in humans are inconsistent. However, AA may mediate its protective action against CHD via its function as an antioxidant, inhibiting lipid peroxidation and regenerating α-tocopherol. Although AA can exert potentially beneficial effects, excessive AA administration can lead to damaging effects via interactions with transition metals, such as iron and copper.
关键词：ascorbic acid;coronary heart disease;lipid metabolism;antioxidants;copper;iron