文章基本信息

标题：Ethanol Effects on Intestinal Functions in Giardia lamblia-Infected Rats
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作者：Nidhi MITTAL ; Joginder Pal NAGPAUL ; Safrun MAHMOOD 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1999
卷号：26
期号：1
页码：17-25
DOI：10.3164/jcbn.26.17
出版社：The Society for Free Radical Research Japan
摘要：The effect of Giardia lamblia infection on D-glucose uptake and brush-border enzymes was studied in chronically ethanol-fed rats. Giardia lamblia trophozoites counts were significantly lower in the intestine of ethanol-fed rats than in the controls. Also, the Na⁺-dependent uptake of D-glucose and brush-border enzymes was significantly reduced ( p <0.0001, p <0.01, respectively) in the G. lamblia -infected rat intestine. There was no change in Na⁺-independent glucose uptake under these conditions. Levels of mRNA encoding Na⁺-dependent D-glucose transporter (SGLT1) and brush-border sucrase and lactase were reduced in G. lamblia -infected animals compared with those of the controls. However, the mRNA levels encoding these proteins in ethanol-fed and control animals were similar in rat intestine. These findings suggest that down-regulation of SGLT1 and disaccharidases could be responsible for the observed D-glucose malabsorption and decrease in the activity of disaccharidases in G. lamblia infection.
关键词：Giardia lamblia;ethanol feeding;malabsorption;sugar transport (D-glucose);disaccharidases