文章基本信息

标题：Correlation between Disease Stage and Activity of Elastase of PMN Origin in the Serum from IgA Nephropathy Patients
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作者：Akihiro KOJIMA ; Mitsune YAMAGUCHI ; Tomoji KOCHA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1998
卷号：24
期号：3
页码：157-165
DOI：10.3164/jcbn.24.157
出版社：The Society for Free Radical Research Japan
摘要：Activities of various enzymes including elastase were determined in sera from healthy control and from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IgA nephropathy (IgA NP), and other renal failures. In IgA NP, the activity of elastase increased significantly in parallel with the disease stage. It correlated well with the increase in the amount of polymorphonuclear leukocyte-elastase (PMN-elastase)·α₁-antitrypsin complex assayed by ELISA, with the increase in myeloperoxidase (MPO) activity, and also with the increase in proteinuria. Studies on both substrate and inhibitor specificities of the elastase showed that the enzyme is indeed from PMN.
关键词：IgA nephropathy;PMN-elastase;myeloperoxidase;serum;polymorphonuclear leukocyte