文章基本信息

标题：Mitochondrial Genotype Frequent in Centenarians Predisposes Resistance to Adult-Onset Diseases
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作者：Jian-Sheng GONG ; Jin ZHANG ; Makoto YONEDA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1998
卷号：24
期号：2
页码：105-111
DOI：10.3164/jcbn.24.105
出版社：The Society for Free Radical Research Japan
摘要：To identify a mitochondrial genotype associated with longevity, we analyzed the entire coding regions of mitochondrial DNA (mtDNA) from 11 centenarians. A C-to-A transversion at nucleotide position (np) 5178 within the ND2 gene, causing a Leu-to-Met replacement; a C-to-T transition at np 8414 within the ATP8 gene, causing a Leu-to-Phe replacement; and a G-to-A transition at np 3010 within the 16S rRNA gene were more frequently observed in the centenarians than in 43 controls. Among these variations, we focused on Mt5178A and screened 37 centenarians and 252 healthy blood donors. The frequency of MtS178A was significantly higher in the centenarians (62%) than in the blood donors (45%). To evaluate the effect of mtDNA variations on the occurrence of diseases, we analyzed the frequencies of Mt5178A and Mt5178C in 338 randomly selected patients. The age distribution of the patients indicated that the frequency of Mt5178C was almost the same as that of Mt5178A among the young patients, whereas the frequency of Mt5178C increased more markedly than that of Mt5178A among old patients. The difference in the frequencies between Mt5178A and Mt5178C was less marked in old male patients than in old female ones; the protective effect of Mt5178A against occurrence of adult-onset diseases may be weaker in males than in females. The ratio of Mt5178 A/C was significantly lower in the old patients than in both the centenarians and the healthy controls. These results suggest that to carry an mtDNA genotype predisposing resistance to adult-onset diseases is one of the genetic factors for longevity.
关键词：mitochondrial DNA;NADH dehydrogenase;adult-onset diseases;longevity;centenarian