文章基本信息

标题：Anti-Proliferative Effects on Human Colon Cancer Cells of Combined Treatment with Cationic Liposome-Entrapped Human Interferon-, β or -γGene and Anti-Cancer Drug
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作者：Minoru SHIMIZU ; Seiji AKIYAMA ; Katsuki ITO 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：23
期号：2
页码：77-83
DOI：10.3164/jcbn.23.77
出版社：The Society for Free Radical Research Japan
摘要：Effects on cultured human colon cancer cells of combination of transfection with cationic multilamellar liposome-entrapped plasmids containing cDNA of human interferon-β (hIFN-β) or interferon-γ (hIFN-γ) (RN-hIFN-γ or RN-hIFN-γ) and an anti-cancer drug (5-fluorouracil or cisplatin) were examined. At 16h after the addition of liposome-entrapped RN-hIFN-β or RN-hIFN-γ, the medium was exchanged for the fresh medium containing anti-cancer drug, of which effect of growth inhibition was strengthened synergistically, and the efficacy increased corresponding to the dose of the drug.
关键词：gene transfection;interferon-β;interferon-γ;5-fluorouracil;cisplatin