文章基本信息

标题：Toxic Effect of Methacrylonitrile on Rat Lung
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作者：Thangavel SAMIKKANNU ; Sivasithamparam NIRANJALI DEVARAJ
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：23
期号：1
页码：27-31
DOI：10.3164/jcbn.23.27
出版社：The Society for Free Radical Research Japan
摘要：Oral administration of methacrylonitrile (MeAN) (100mg/kg body wt/day) to rats for 14 days damaged the lung tissue and altered the bronchoalveolar lavage (BAL) angiotensin-converting enzyme activity (ACE) and levels of phospholipids and surfactant phospholipids. However, there was no alteration in BAL lactate content or lactate dehydrogenase activity. A significant increase in the phosphatidylcholine content in the extracellular surfactant indicates Type-II cell proliferation. MeAN caused the lung injury by increasing alveolar capillary permeability and promoting the accumulation of surfactant phospholipids, which may lead to serious conditions such as fibrosis.
关键词：methacrylonitrile;lung lavage;ACE;phospholipids;surfactant