文章基本信息

标题：Long-Term Ovariectomy Effect on Plasma Glucose, Lipids, Antioxidant Vitamins, and Lipid Peroxides
本地全文：下载
作者：Christelle DOUILLET ; Francoise BORSON-CHAZOT ; Serge RENAUD 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：23
期号：1
页码：15-25
DOI：10.3164/jcbn.23.15
出版社：The Society for Free Radical Research Japan
摘要：This study was performed to determine plasma lipid changes and antioxidant status in relation to cholesterol content and fatty acid distribution in the aorta of rats after long-term ovariectomy (OV). After 12 months, OV induced in rat plasma a significant increase in glucose, total cholesterol, and triglycerides compared with the corresponding values for the control rats (C) of the same age ( p <0.0005, p <0.005, p <0.000S, respectively). These changes were associated with a significant increase in lipid peroxide level ( p <0.05) and a significant decrease in vitamin E in the plasma from group OV compared with the group C level ( p <0.0001). Conversely, OV after 7 and 12 months induced a significant increase in vitamin C ( p <0.001, p <0.0001, respectively). Concerning plasma fatty acid distribution, after 12 months, OV caused a significant increase in gamma and dihomo gamma linolenic acid ( p <0.0005, p <0.05, respectively). These changes were associated with a significant increase in aortic cholesterol in group OV ( p <0.0005), and a significant decrease in the percentage of arachidonic acid ( p <0.005) and of the total amount of fatty acids of the n-3 series ( p <0.0001) and plasmalogen fatty acids (C16:0, p <0.005; C 18:0, p <0.05) compared with the corresponding values for group C. These results show that OV induced, independently of any effects of aging, plasma-specific lipid alterations with dysregulation of oxidative status, which could be crucial in the development of atherothrombotic disease.
关键词：ovariectomy;antioxidant vitamins;lipid peroxides;aortic lipids;fatty acids