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标题：Antimutagenic and Anticarcinogenic Activity of Emblica officinalis Gaertn
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作者：Jeena K. JOSE ; Girija KUTTAN ; Josely GEORGE 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：22
期号：3
页码：171-176
DOI：10.3164/jcbn.22.171
出版社：The Society for Free Radical Research Japan
摘要：Aqueous extracts of Emblica officinalis and Chyavanaprash , an indigenous drug preparation in which Emblica officinalis is a major ingredient, were found to inhibit 20-methylcholanthrene-induced sarcoma and to increase the life span of the animals. Oral administration of Emblica (10mg/mice) and Chyavanaprash (50mg/mice) extracts produced a 75% reduction in the development of sarcoma. The aqueous extract of Emblica was also found to inhibit the activation and mutagenicity of 2-acetamidofluorene (2-AAF) as well as that of direct-acting mutagens N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and 4-nitro-O-phenylenediamine (4-NPDA). The extract was found to inhibit microsomal P-450 enzyme, aniline hydroxylase. The activity of the extract may be mainly related to its oxygen radical-scavenging activity as well as to inhibition of Phase-I enzymes.
关键词：Emblica officinalis;20-methylcholanthrene;antimutagenesis;anticarcinogenesis;Phase-I enzymes