文章基本信息

标题：Comparative Effects of Dietary Fat Manipulation on Fatty Acid Composition of Rat Stomach, Jejunum, and Colon Phospholipids
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作者：Manohar GARG ; Robert BLAKE ; Brenda REINHARD 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1997
卷号：22
期号：2
页码：101-111
DOI：10.3164/jcbn.22.101
出版社：The Society for Free Radical Research Japan
摘要：The phospholipid fatty acid composition of three parts of gastrointestinal tract (GIT) possessing different functions (stomach, jejunum, and colon) was examined to determine if these gut segments consistently respond to dietary fat. Three groups of eight weanling male Sprague-Dawley rats were fed one of three isocaloric, semi-synthetic, nutritionally adequate diets for six weeks. The fat type in the control diet was primarily beef tallow supplemented with sufficient linoleic acid (18: 2n-6) to prevent essential fatty acid deficiency, the n-6 diet contained high levels of 18:2n-6, and the n-3 diet provided high levels of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids with similar levels of 18:2n-6 as in the control diet. Feeding the n-3 diet resulted in the incorporation of 20:5n-3 and 22:6n-3 into all the GIT segments examined; however, the incorporation was significantly higher in the jejunum and the colon, compared with that in the stomach, phospholipids. The arachidonic acid (20:4n-6) content was lower in the stomach, jejunum, and colon phospholipids following the feeding of the n-3 diet. The 18: 2n-6 content was found to be higher following consumption of the n-3 diet compared with that found for the control diet. The 20:4n-6 content was significantly higher in the jejunum than in the colon or stomach phospholipids, whereas the 18:2n-6 content was consistently higher in all the GIT segments in animals fed the n-6 diet. This diet group also exhibited lower levels of monounsaturated fatty acids in the stomach and lower levels of saturated fatty acids in the jejunum and the colon phospholipids. Thus, dietary fat manipulations inconsistently influence the phospholipid fatty acid composition of various parts of the GIT, suggesting that the functioning of the stomach, jejunum, and colon may be affected differently by alterations in the type of dietary fat ingested.
关键词：dietary fats;n-6 fatty acids;n-3 fatty acids;fatty acid composition;gastrointestinal tract