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标题：Dehydroepiandrosterone-Sulphate Secretion and State of Adrenal Function in the Rat
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作者：Thomas REMER ; Klaus PIETRZIK ; Herbert WIELAND 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：2
期号：2
页码：141-152
DOI：10.3164/jcbn.2.141
出版社：The Society for Free Radical Research Japan
摘要：This study was undertaken to gain better insight into dehydroepiandrosterone-sulphate (DHEA-S) secretion in rats, which is necessary for the subsequent investigation of the influence of nutritional status on DHEA-S secretion in this species (published as part II). DHEA-S as well as corticosterone (11-OHCS) blood levels were found to be markedly lower in dexamethasone-treated than in untreated rats. After adrenocorticotropic hormone (ACTH) administration DHEA-S and 11-OHCS increased significantly. A similar rise was seen for DHEA-S in metyrapone-treated rats. At the same time these animals exhibited a drastic elevation of 11-desoxycorticosterone (11-DOC). Furthermore DHEA-S levels of rats pretreated with ACTH prior to metyrapone application significantly exceeded the DHEA-S values measured in animals only given metyrapone. However, the DHEA-S level did not change clearly in rats treated with either a single or multiple doses of hCG, although the concentrations of DHEA, androstenedione, and testosterone were markedly elevated in these animals. These findings suggest that DHEA-S in rats is secreted chiefly (or exclusively) by the adrenal gland. Since a stimulative effect of ACTH pretreatment on the secretory DHEA-S response to subsequent metyrapone stimulation could be demonstrated, we conclude that stress (ACTH administration) associated with a stimulation of adrenal gland activity provokes an increase in the secretory capacity for DHEA-S.
关键词：DHEA (-S);corticosterone;11-desoxycorticosterone;androstenedione;testosterone