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标题：Elevation of the Mitochondrial Oxidative Activity of Rat Liver by Long-Term Intake of a High-Fat Diet Based on Beef Tallow or Safflower Oil
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作者：Taro MURAKAMI ; Yoshiharu SHIMOMURA ; Tomohiro TAMURA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1995
卷号：19
期号：3
页码：155-163
DOI：10.3164/jcbn.19.155
出版社：The Society for Free Radical Research Japan
摘要：Using rats we examined the effects on liver mitochondrial functions of the long-term intake of a high-fat diet based on beef tallow or safflower oil. Forty-eight rats were divided into three dietary groups: a low-fat diet group and two high-fat ones (beef tallow and safflower oil). The low-fat diet provided 7, 73, and 20% of the total energy as fat, carbohydrate, and protein, respectively; and two high-fat diets, 45, 35, and 20% of energy, respectively. Rats were isoenergetically fed the appropriate diet for 4 months. The state-3 respiration of the mitochondria was significantly higher in the two high-fat diet groups than in the low-fat diet group, when both succinate and β-hydroxybutyrate were used as substrates for the respiration. However, there was no difference between the two high-fat diet groups. The groups were ranked in terms of cytochrome a content in their mitochondria as follows: low-fat diet group
关键词：safflower oil;beef tallow;liver;mitochondria;oxidative capacity;rat