文章基本信息

标题：Inhibition of Ammonia-Chloramine Generation and of Damage to Vascular Endothelium by Taurine and β-Alanine
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作者：Yoshihiro YOSHIMURA ; Hitoshi HOSHINO ; Katsumi UCHIYAMA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1995
卷号：18
期号：1
页码：11-18
DOI：10.3164/jcbn.18.11
出版社：The Society for Free Radical Research Japan
摘要：Hypochlorous acid (HOCl) produced by myeloperoxidase reacts with ammonia to form highly toxic ammonia-chloramine (NH₂Cl) in vivo . We examined the abilities of various amino acids to compete with ammonia to form only mildly toxic chloramines with HOCl. Amino acid-chloramines (RNHCl) were generated by reacting amino acids with HOCl, and showed maximum absorption near 250nm. Glycine, taurine, and β-alanine readily formed hydrophilic chloramines with high absorption at 250nm. The ESR spectrum of HOCl changed to that of RNHCl by reacting HOCl with each of these three amino acids. Taurine and β-alanine inhibited vascular endothelium lesions due to active oxygen species generated by neutrophils that had been stimulated by opsonized zymosan and phorbol myristate acetate.
关键词：ammonia-chloramine;inflammation;amino acids;active oxygen species