文章基本信息

标题：Safflower Oil Diet Decreases Hepatic Acetyl CoA-Carboxylase Activity by Increasing α1-Adrenergic Stimulation in Rats
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作者：Tatsuhiro MATSUO ; Masashige SUZUKI
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1994
卷号：17
期号：3
页码：179-188
DOI：10.3164/jcbn.17.179
出版社：The Society for Free Radical Research Japan
摘要：Effects of dietary fats consisting of different fatty acids on the acetyl CoA-carboxylase activity in liver was studied in rats. Sprague-Dawley male rats were meal-fed an isoenergetic diet based on either beef tallow or safflower oil for 8 weeks. The acetyl CoA-carboxylase activity in liver was lower in the safflower oil diet group than in the beef tallow diet group. Body fat accumulation was less in rats fed the safflower oil diet, however, their norepinephrine turnover rate in liver was higher. α₁-Adrenergic receptor binding was determined with [³H] prazosin. Binding affinity of α₁-adrenergic receptor in liver was higher in the safflower oil diet group, presumably resulting from higher membrane fluidity in that group. These results suggest that the intake of the safflower oil diet promoted less body fat accumulation by reducing the acetyl CoA-carboxylase activity, which may be a result of higher sympathetic nervous system activity in the liver.
关键词：acetyl CoA-carboxylase;norepinephrine turnover;α1-adrenergic receptor;safflower oil;beef tallow