文章基本信息

标题：The Relationship between Chemiluminescence Intensity and Genotoxicity in Polyaromatic Hydrocarbons and Aflatoxins
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作者：Kazumi OSADA ; Yuji FURUKAWA ; Michio KOMAI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1994
卷号：17
期号：2
页码：111-117
DOI：10.3164/jcbn.17.111
出版社：The Society for Free Radical Research Japan
摘要：The chemiluminescence (CL) emitted from polyaromatic hydrocarbons (PAH) and aflatoxins (AF) in an S9 mix system can be detected by use of a chemiluminescence analyzer. These CL intensities were significantly correlated with the degree of mutagenicity as measured by the Ames test (using S. typhimurium TA 100), and of clastogenicity measured by the micronucleus test using ICR mice. The emission spectra of the CL detected from aflatoxin B1 (AFB1) indicated a distinctive blue light around 440nm. In the case of AFs, there was a strong correlation between CL intensity and genotoxicity. CL intensity detected from nonsubstitutional polyaromatic hydrocarbons was significantly correlated with the degree of superdelocalizability. These CL emissions observed from PAHs and AFs not only correspond to the genotoxicity of these compounds but also reflect the electronic configuration of them.
关键词：chemiluminescence;polyaromatic hydrocarbons;aflatoxins;micronucleus test;Ames test