文章基本信息

标题：Tumor-Reducing and Antioxidant Activities of Sydnone-Substituted Chalcones
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作者：Ruby John ANTO ; Girija KUTTAN ; Ramadasan KUTTAN 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1994
卷号：17
期号：2
页码：73-80
DOI：10.3164/jcbn.17.73
出版社：The Society for Free Radical Research Japan
摘要：Tumor-reducing effect in vivo and antioxidant effect in vitro of 12 sydnone-substituted chalcones having various groups on the benzene ring were studied. All of them were found to be cytotoxic to tumor cells in vitro , while only methyl substitution increased the in vivo tumor-reducing activity. Some of the substituted chalcones were found to inhibit lipid peroxidation and scavenge superoxides and hydroxyl radicals in vitro . The biological activities of the chalcones were compared with those of curcumin I, an analog of chalcone with known antioxidant activity; and although the sydnone-substituted chalcones had higher cytotoxicity than curcumin I, their tumor-reducing and antioxidant activity were lower. Tumor-reducing activity was found to be independent of their antioxidant activity.
关键词：chalcones;sydnone-substituted chalcone;antitumor activity;antioxidant activity