文章基本信息

标题：Lack of Vasopressin Response to Water Deprivation in Blind Hereditary Microphthalmic Rats with Abnormal Suprachiasmatic Nuclei
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作者：Katsuya NAGAI ; Alexander G. STOYNEV ; Nobuo NAGAI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1993
卷号：14
期号：3
页码：163-169
DOI：10.3164/jcbn.14.163
出版社：The Society for Free Radical Research Japan
摘要：We compared the plasma arginine-vasopressin (AVP) concentrations and hematocrit values before and after 24-h water-deprivation in normal Donryu rats and blind hereditary microphthalmic rats having a morphologically abnormal suprachiasmatic nucleus (SCN) in the hypothalamus, but a persistent circadian rhythm. We found that in the microphthalmic rats hypovolemia-induced elevation of the plasma AVP concentration was suppressed. The fact that these microphthalmic rats had a free-running circadian rhythm in their locomotor activity indicates that the cells comprising the circadian oscillator are functionally intact. Thus, we propose that SCN cells other than circadian pacemaker cells are involved in regulation of the plasma vasopressin concentration.
关键词：hypovolemia;antidiuretic hormone;hematocrit;water balance