文章基本信息

标题：Impact of Quercetin Consumption on Phase-I and Phase-II Drug-Metabolizing Enzymes in Mice
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作者：Rajinder Kaur GANDHI ; Krishan Lal KHANDUJA
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1993
卷号：14
期号：2
页码：107-112
DOI：10.3164/jcbn.14.107
出版社：The Society for Free Radical Research Japan
摘要：In the present study Swiss NMRI mice were fed quercetin, a naturally-occurring dietary polyphenolic flavonoid, through their drinking water at dose levels of 0, 1, 3, and 9μg/ml for 8 weeks. There was no change in the hepatic and pulmonary levels of arylhydrocarbon hydroxylase, cytochrome P-450, cytochrome b ₅, cytochrome c -reductase, or UDP-glucuronyltransferase due to quercetin feeding. However, hepatic activity of glutathione-S-transferase was significantly increased at 3 and 9μg/ml dose levels; and that of the pulmonary enzyme, at 9μg/ml dose. Levels of reduced glutathione were significantly elevated in liver and lungs. These increases in glutathione-S-transferase and reduced glutathione may protect the liver and lungs from the carcinogenic insult of chemicals through the detoxification process.
关键词：quercetin;glutathione-S-transferase;reduced glutathione;arylhydrocarbon hydroxylase;cytochrome P-450