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标题：Effect of Cu2+ on Prostaglandin Synthesis and Catabolism in Rabbit Gastric Antral Mucosal Slices In Vitro
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作者：Yohko FUJIMOTO ; Hiroko NISHIDA ; Keiko UCHIDA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1993
卷号：14
期号：1
页码：45-51
DOI：10.3164/jcbn.14.45
出版社：The Society for Free Radical Research Japan
摘要：The effects of Fe²⁺ and Cu²⁺ on prostaglandin (PG) synthesis and catabolism in rabbit gastric antral mucosal slices have been compared. Fe²⁺ markedly promoted the lipid peroxidation of gastric mucosal slices. The lipid peroxidation induced by Fe²⁺ inhibited the formation of all four PGs examined (PGE₂, PGF_2α, 13, 14-dihydro-15-keto PGE₂ and 13, 14-dihydro-15-keto PGF_2α) to a similar extent. While Cu²⁺ produced only a small increase in lipid peroxidation, it had a powerful stimulatory effect on PGE₂ and PGF_2α formation. Cu²⁺ induced no change in the formation of 13, 14-dihydro-15-keto PGE₂ and 13, 14-dihydro-15-keto PGF_2α. Moreover, tert -butyl hydroperoxide stimulated the formation of all four PGs at low concentrations (5 and 10μM), but inhibited it at a high concentration (1, 000μM). These results suggest that Cu²⁺ has the potential to increase the levels of biologically active PGs in gastric mucosa by affecting the activities of both PG cyclo-oxygenase and PG-catabolizing enzymes.
关键词：Fe2+;Cu2+;prostaglandin synthesis;prostaglandin catabolism;gastric mucosa