文章基本信息

标题：Deficiency of Galactosidase Activity in Multiple Organs in GM2-Deficient Mice
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作者：Takaaki AOYAGI ; Taka OSANAI ; Takao WADA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1992
卷号：13
期号：3
页码：189-197
DOI：10.3164/jcbn.13.189
出版社：The Society for Free Radical Research Japan
摘要：WHT/Ht mice are known to have GM2 deficiency especially in the liver. In order to know the relationship of this abnormality to the general metabolism in organs or cells, we compared 17 hydrolytic enzyme activities in the liver, brain, spleen, and kidney between the WHT/Ht mice and control BALB/c mice or without administration of GM2 and GM3. Regardless of the GM2 or GM3 treatment, the galactosidase activity was markedly low in all of the tested organs in the WHT/Ht mice when compared with that in the control animals. This consistency stands in contrast with the known organ-dependent heterogeneity of ganglioside expression and thus indicates independency of the GM2 deficiency from the galactosidase deficiency in this model animal.
关键词：gangliosides;WHT/Ht mouse;GM2 deficiency;proteases;glycosidases