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标题：Protective Effect of a Benzoquinone Derivative on the Injury to Cultured Aortic Endothelial Cells Induced by Linoleic Acid Hydroperoxide
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作者：Vladimir A. KOSTYUK ; Sadaaki KOMURA ; Nobuko OHISHI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1992
卷号：12
期号：2
页码：69-75
DOI：10.3164/jcbn.12.69
出版社：The Society for Free Radical Research Japan
摘要：Effect of a water-soluble benzoquinone derivative, 4-[4-N-(5-ethyl-1-thia-3, 4-diazol-2-yl)sulfophenylamino]-5-methoxy-1, 2-benzoquinone, on the injury to cultured aortic endothelial cells induced by linoleic acid hydroperoxide was examined. The benzoquinone derivative markedly inhibited the release of lactate dehydrogenase(LDH) from the cells into the medium in a concentration-dependent manner. The inhibitory effect of the benzoquinone derivative tended to be higher than that of butylated hydroxytoluene. Upon incubation of the endothelial cells with the hydroperoxide, the lipid peroxide level in the cells was increased prior to the release of LDH from the cells, and this increase was significantly inhibited by the novel antioxidant.
关键词：endothelial cells;linoleic acid hydroperoxide;cell injury;benzoquinone