文章基本信息

标题：Imaging of Rat Head under Ischemic Conditions by Near-Infrared Computed Tomography
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作者：Rentaro ABUMI ; Katsuya NAGAI ; Yasunobu ITOH 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1991
卷号：11
期号：3
页码：211-222
DOI：10.3164/jcbn.11.211
出版社：The Society for Free Radical Research Japan
摘要：Light in the near-infrared range (700-1, 200nm) penetrates living tissues including the skull. Oxy- and deoxy-hemoglobin contents in living tissue can be measured from the absorbance in this range. Myoglobin and cytochrome oxidase also have their absorbance in this range. Therefore, we carried out near-infrared computed tomography by a modification of the method for X-ray CT for humans. Three semiconductor lasers were used as light sources with a laser beam scanner. The transmitted light was measured with a linear detector equipped with 25 photomultipliers. With this device, we constructed images of the heads of anesthetized rats from the differences between the absorbance data at 780 and 805nm. The brightness of the head images increased in rats with ischemia induced by occlusion of four vessels (carotid). The ischemic area in the central part of the head was shown on exchange transfusion of the blood with perfluorochemical emulsion.
关键词：semiconductor laser;near-infrared spectrophotometry;functional image;hemoglobin oxygenation;CT