文章基本信息

标题：Modulation of Intracerebral Glycosidase Activities by Intraperitoneal Administration of Glycosidase Inhibitors
本地全文：下载
作者：Takaaki AOYAGI ; Taka OSANAI ; Takao WADA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1991
卷号：10
期号：3
页码：197-208
DOI：10.3164/jcbn.10.197
出版社：The Society for Free Radical Research Japan
摘要：When administered to mice, enzyme inhibitors exert extensive effects that cannot be expected from their direct actions. On the basis of our previous observations [1], we tested how glycosidase inhibitors influence the intracerebral activities of various hydrolytic enzymes including glycosidases. The results showed that, when administered intraperitoneally, mannostatin and nagstatin stimulated, while siastatin and pyridindolol suppressed, intracerebral activities of glycosidases. The effects showed dose dependency. Although the above inhibitors influenced various other enzymatic activities as well, no particular significance could be attached to such effects because of the absence of dose dependency.
关键词：intracerebral enzymes;proteases;glycosidases;inhibitors