文章基本信息

标题：Cholesterol Sulfate-Containing Liposomes Entrapping Adriamycin. Pharmacokinetics and Antineoplastic Effect
本地全文：下载
作者：Hitoshi NODA ; Tomio OGASAWARA ; Hidefumi YAMAKAWA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1991
卷号：10
期号：3
页码：181-188
DOI：10.3164/jcbn.10.181
出版社：The Society for Free Radical Research Japan
摘要：Pharmacokinetics and antineoplastic effect of adriamycin (ADM) entrapped in multilamellar vesicles of liposomes composed of egg phosphatidylcholine (PC), cholesterol (Chol), and cholesterol sulfate (CholSO₄) in a molar ratio of 6:3:1 were studied. Upon its intravenous injection, the blood level of ADM remained higher for 24h than that of ADM entrapped in liposomes composed of PC, Chol, and sulfatide (CSE) in a molar ratio of 5:4:1 and than that of free ADM. Entrapment of ADM in liposomes containing either CholSO₄ or CSE reduced the concentration of ADM in the heart and kidney compared with free ADM. In the liver, however, the level of ADM, when the drug entrapped in CholSO₄-containing liposomes was injected, was similar to that of ADM injected in free form, while the drug markedly accumulated in this organ, when ADM was entrapped in CSE-containing liposomes. By using P388 leukemia of mice, we demonstrated that ADM entrapped in CholSO₄-containing liposomes has higher antineoplastic activity than free ADM.
关键词：cholesterol sulfate;liposomes;adriamycin;pharmacokinetics;antineoplastic effect