文章基本信息

标题：Preparation and Some Properties of Cholesterol Sulfate-Containing Liposomes Entrapping Adriamycin
本地全文：下载
作者：Hitoshi NODA ; Tomio OGASAWARA ; Hidefumi YAMAKAWA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1991
卷号：10
期号：2
页码：83-91
DOI：10.3164/jcbn.10.83
出版社：The Society for Free Radical Research Japan
摘要：Cholesterol sulfate (CholSO₄) was found to be a useful substitute of sulfatide for the preparation of negatively charged liposomes entrapping adriamycin (ADM). Liposomes composed of egg phosphatidylcholine, cholesterol, and CholSO₄ in a molar ratio of 6:3:1 entrapped ADM efficiently and reduced the leakage of the entrapped ADM from the liposomes to the same degree as found for sulfatide-containing liposomes. The novel liposomes induced neither haemolysis nor platelet aggregation
关键词：cholesterol sulfate;liposomes;adriamycin;haemolysis;platelet aggregation