文章基本信息

标题：Increase in Lipid Peroxidation in Rat Gastric Mucosal Lesions Induced by Water-Immersion Restraint Stress
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作者：Toshikazu YOSHIKAWA ; Haruo MIYAGAWA ; Norimasa YOSHIDA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1986
卷号：1
期号：3
页码：271-277
DOI：10.3164/jcbn.1.271
出版社：The Society for Free Radical Research Japan
摘要：The role of lipid peroxidation in the pathogenesis of gastric ulcer was investigated in a rat model produced by water-immersion restraint stress. After the immersion of rats in 23°C water with restraint, blood flow of the gastric wall was significantly decreased and hemorrhagic erosions were seen in the body of the stomach. Thiobarbituric acid-reactive substances, an index of lipid peroxidation, in the gastric mucosa were significantly increased after the stress. These results suggest that lipid peroxidation may play a role in the pathogenesis of gastric mucosal lesions induced by stress.
关键词：gastric mucosal lesions;lipid peroxidation;microcirculation;thiobarbituric acid-reactive substances;water-immersed restraint stress