文章基本信息

标题：Enzymatic Changes in Pancreas and Liver of the KK Mouse As an Animal Model of Diabetes Mellitus
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作者：Takaaki AOYAGI ; Takao WADA ; Fukiko KOJIMA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1986
卷号：1
期号：3
页码：247-256
DOI：10.3164/jcbn.1.247
出版社：The Society for Free Radical Research Japan
摘要：KK mice are used as model animals for non-insulin-dependent diabetes. In order to better understand the biochemical features of these animals, we compared the activities of various hydrolytic enzymes, including aminopeptidases, endopeptidases, carboxypeptidase, esterase, and so forth in the pancreas and liver of these animals with the same enzymes in ICR mice as controls. The enzymatic changes in the model animals were extensive not only in pancreas but also in liver. Multivariate analysis showed that the metabolic changes in liver rather than in pancreas are closely related to the abnormal glucose metabolism in KK mice. This may be somehow related to the insulin resistance in peripheral tissues in this model.
关键词：proteases;pancreas;liver;diabetes mellitus;KK mouse