文章基本信息

标题：Parallel Inhibition of Islet Glucokinase and Glucose-Stimulated Insulin Secretion by Either Alloxan or Ninhydrin
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作者：Ichitomo MIWA ; Hiroshi HARA ; Jun OKUDA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1986
卷号：1
期号：3
页码：237-245
DOI：10.3164/jcbn.1.237
出版社：The Society for Free Radical Research Japan
摘要：Treatment of pancreatic islets with alloxan or ninhydrin at concentrations that induced the inhibition of glucokinase activity similarly inhibited glucose-stimulated insulin secretion. Alloxan- or ninhydrin-induced inhibition of glucokinase activity was blocked by the presence of hexoses, which also protected against the inhibitory effect of each drug on insulin secretion. The protective effect of D-glucose against the inhibition of glucokinase activity by alloxan or ninhydrin showed α-anomeric preference, which was similarly observed in the protection by the sugar against the inhibition of insulin secretion. These results suggest that the inhibition of glucose-stimulated insulin secretion by treatment of pancreatic islets with alloxan or ninhydrin is due to the inhibition of glucokinase.
关键词：glucokinase;insulin secretion;alloxan;ninhydrin;pancreatic islet