文章基本信息

标题：A Novel Uncoupler of Mitochondrial Respiration, 9, 10-Epoxy-12-octadecenoate, Exists in Human Burned Skin
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作者：Kazuhisa YOKOO ; Mika HAYAKAWA ; Satoru SUGIYAMA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1986
卷号：1
期号：2
页码：121-127
DOI：10.3164/jcbn.1.121
出版社：The Society for Free Radical Research Japan
摘要：In human burned skin, several polyunsaturated fatty acids, especially linoleate and its peroxide were isolated by high-performance liquid chromatography. Chemical structure of the epoxide was determined to be 9, 10-epoxy-12-octadecenoate by gas-chromatography/mass spectrometry, nuclear magnetic resonance measurements and ozonolysis. The epoxide showed an uncoupling activity to liver mitochondrial respiration and diminished the respiratory control of mitochondria. Formation of the epoxide in the burned skin was related to clinical observation of the “burn toxin” which appears after severe burns.
关键词：epoxy-linoleate;burn toxin;mitochondrial respiration;uncoupler;human skin