文章基本信息

标题：Biomechanical and Biophysical Properties of Skin Collagen in Riboflavin or Pyridoxine Deficient Rats
本地全文：下载
作者：Rajani PRASAD ; A. V. LAKSHMI ; Mahtab S. BAMJI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1986
卷号：1
期号：1
页码：59-64
DOI：10.3164/jcbn.1.59
出版社：The Society for Free Radical Research Japan
摘要：Skin collagen samples from vitamin B₂- or B₆-deficient rats, weight-matched controls, and control rats fed ad libitum were examined for biomechanical and biophysical properties like tensile strength, shrinkage temperature, gel-reversibility of salt-soluble collagen, and susceptibility of insoluble collagen to denaturing and proteolytic agents. Deficiencies of riboflavin and pyridoxine, as well as food restriction, significantly reduced the tensile strength and shrinkage temperature and increased the gel-reversibility of collagen. The changes tended to be of greater magnitude in collagen from the vitamin-deficient rats. Solubilization of insoluble collagen by denaturing and proteolytic agents was markedly increased in collagen from riboflavin- or pyridoxine-deficient animals but not in that from food-restricted rats. The results of this study support the hypothesis that the skin changes seen in riboflavin and pyridoxine deficiencies may be due to impaired collagen cross-linking and consequent alterations in the physical properties of the skin.
关键词：tensile strength;skin collagen;riboflavin deficiency;pyridoxine deficiency;shrinkage temperature