文章基本信息

标题：The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review
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作者：Alexandru Florin Rogobete ; Dorel Sandesc ; Marius Papurica 等
期刊名称：Burns & Trauma
印刷版ISSN：2321-3876
出版年度：2017
卷号：5
期号：1
页码：8
DOI：10.1186/s41038-017-0073-0
语种：English
出版社：BioMed Central
摘要：The critically ill polytrauma patient presents with a series of associated pathophysiologies secondary to the traumatic injuries. The most important include systemic inflammatory response syndrome (SIRS), sepsis, oxidative stress (OS), metabolic disorders, and finally multiple organ dysfunction syndrome (MODS) and death. The poor outcome of these patients is related to the association of the aforementioned pathologies. The nutrition of the critically ill polytrauma patient is a distinct challenge because of the rapid changes in terms of energetic needs associated with hypermetabolism, sepsis, SIRS, and OS. Moreover, it has been proven that inadequate nutrition can prolong the time spent on a mechanical ventilator and the length of stay in an intensive care unit (ICU). A series of mathematical equations can predict the energy expenditure (EE), but they have disadvantages, such as the fact that they cannot predict the EE accurately in the case of patients with hypermetabolism. Indirect calorimetry (IC) is another method used for evaluating and monitoring the energy status of critically ill patients. In this update paper, we present a series of pathophysiological aspects associated with the metabolic disaster affecting the critically ill polytrauma patient. Furthermore, we present different non-invasive monitoring methods that could help the intensive care physician in the adequate management of this type of patient.
关键词：Critically ill ; Energy expenditure ; Indirect calorimetry ; Metabolic disaster ; Oxidative stress ; Overfeeding ; Underfeeding ; Polytrauma