文章基本信息

标题：La biología sintética como desafío para comprender la autonomía de lo vivo
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作者：Sara Murillo-Sánchez ; Kepa Ruiz-Mirazo
期刊名称：Isegoría
印刷版ISSN：1988-8376
出版年度：2016
期号：55
页码：551-575
语种：Spanish
出版社：Consejo Superior de Investigaciones Científicas
摘要：We here offer an alternative view of synthetic biology, quite distant from the engineering approaches that currently set the main research agenda of the field. Our analysis centres on those lines of work, both theoretical and experimental, whose primary objective is understanding the living phenomenon per se. A detailed review of several cases of artificial in vitro implementation of ‘self-productive’ chemical systems will help us reflect on the enormous challenge of transforming a descriptive scientific discipline, like biology, into an enterprise that comprises and fosters investigations articulated around the notion of synthesis or fabrication. The challenge is huge because of the intrinsic metabolic nature of biological systems, what makes our efforts to control or build them de novomuch harder, forcing us to develop intervention/implementation platforms at the molecular level that do not threaten that inherent autonomous dimension of the living.
关键词：Self-organization;Autocatalysis;Metabolism;Minimal Cell;Biological Autonomy;Origins of Life;Fabrication;auto-organización;autocatálisis;metabolismo;célula mínima;autonomía biológica;origen de vida;fabricación