文章基本信息

标题：Selection against variants in the genome associated with educational attainment
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作者：Augustine Kong ; Michael L. Frigge ; Gudmar Thorleifsson 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：5
页码：E727-E732
DOI：10.1073/pnas.1612113114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Epidemiological and genetic association studies show that genetics play an important role in the attainment of education. Here, we investigate the effect of this genetic component on the reproductive history of 109,120 Icelanders and the consequent impact on the gene pool over time. We show that an educational attainment polygenic score, POLY_EDU, constructed from results of a recent study is associated with delayed reproduction ( P < 10⁻¹⁰⁰) and fewer children overall. The effect is stronger for women and remains highly significant after adjusting for educational attainment. Based on 129,808 Icelanders born between 1910 and 1990, we find that the average POLY_EDU has been declining at a rate of ∼0.010 standard units per decade, which is substantial on an evolutionary timescale. Most importantly, because POLY_EDU only captures a fraction of the overall underlying genetic component the latter could be declining at a rate that is two to three times faster.
关键词：selection ; educational attainment ; genes ; fertility ; sequence variants