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  • 标题:Effect of Lactobacillus paracasei Culture Filtrates and Artichoke Polyphenols on Cytokine Production by Dendritic Cells
  • 本地全文:下载
  • 作者:Angelo Sisto ; Diomira Luongo
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2016
  • 卷号:8
  • 期号:10
  • 页码:635
  • DOI:10.3390/nu8100635
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:The most recent trend in research on probiotic bacteria aims at the exploitation of bioactive bacterial compounds that are responsible for health-promoting effects and suitable for medical applications. Therefore, the main purpose of this study was to ascertain if the immunomodulatory effects of L. paracasei strains on dendritic cells (DCs) were caused by bacterial metabolites released in the culture medium. For that reason, bacterial strains were grown in two media generally used for the culture of DCs, and the effects of culture filtrates on the maturation of DCs and cytokine production were evaluated. Moreover, to reveal potential synergistic effects on the immunomodulation of DCs, an artichoke phenolic extract (APE) was added to the media before bacterial growth. The experiments pointed out an interesting anti-inflammatory activity of a culture filtrate obtained after growing a probiotic L. paracasei strain in one of the media supplemented with APE. Therefore, this culture filtrate—which combines the anti-inflammatory activity and the other well-known health-promoting properties of artichoke phenolic compounds—could represent the basis for future particular exploitations.
  • 关键词:probiotic bacteria; immunomodulatory bacterial metabolites; dendritic cells; artichoke phenolic compounds probiotic bacteria ; immunomodulatory bacterial metabolites ; dendritic cells ; artichoke phenolic compounds
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