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标题：Analgesic Effect of Indian Gooseberry (Emblica officinalis Fruit) Extracts on Postoperative and Neuropathic Pain in Rats
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作者：Dong Wook Lim
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2016
卷号：8
期号：12
页码：760
DOI：10.3390/nu8120760
语种：English
出版社：MDPI Publishing
摘要：Indian gooseberry (Emblica officinalis fruit), also known as “Amla” is one of the oldest edible fruits known in India. It has also traditionally been used to treat inflammation, and as an analgesic to treat wounds. However, experimental evidence for the analgesic effects of E. officinalis has been lacking. The present study investigated whether E. officinalis extracts exhibit analgesic effects in the plantar incision (PI) and spared nerve injury (SNI) pain-model rats. We evaluated the mechanical withdrawal threshold (MWT) using von Frey filaments, and pain-related behavior was determined after surgery based on ultrasonic vocalization (USV). The group treated with E. officinalis extracts at 300 mg/kg had significantly increased MWT values at 6 h and 24 h after the PI, and had a significantly reduced number of 22–27-kHz USVs at 6 h and 24 h after PI. Moreover, after 15 days of continuous treatment with E. officinalis extracts, the treated group showed significantly alleviated SNI-induced hypersensitivity and reduced pro-inflammatory cytokine levels. Thus, E. officinalis extracts have potential analgesic effects in both postoperative and neuropathic pain models in vivo.
关键词：analgesic effects; anti-inflammation; Emblica officinalis ; Indian gooseberry; pain; plantar incision; spared nerve injury analgesic effects ; anti-inflammation ; Emblica officinalis ; Indian gooseberry ; pain ; plantar incision ; spared nerve injury