文章基本信息

标题：Revealing the dual streams of speech processing
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作者：Julius Fridriksson ; Grigori Yourganov ; Leonardo Bonilha 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2016
卷号：113
期号：52
页码：15108-15113
DOI：10.1073/pnas.1614038114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：SignificanceRelatively recently, the concept of dual route neural architecture, where dorsal and ventral brain regions process information synergistically, has been applied to study of speech processing. Although a large body of work has investigated these streams in relation to human speech processing, there is little consensus regarding specific cortical regions implicated. Relying on extensive behavioral and neuroimaging data from a large sample of stroke survivors, we used a data-driven approach to localize regions crucial for motor-phonological and lexical-semantic aspects of speech processing. Results revealed distinct anatomical boundaries between a dorsal frontoparietal stream supporting a form-to-articulation pathway and a ventral temporal-frontal stream supporting a form-to-meaning pathway. This study shows clear division between two processing routes underlying human speech. Several dual route models of human speech processing have been proposed suggesting a large-scale anatomical division between cortical regions that support motor-phonological aspects vs. lexical-semantic aspects of speech processing. However, to date, there is no complete agreement on what areas subserve each route or the nature of interactions across these routes that enables human speech processing. Relying on an extensive behavioral and neuroimaging assessment of a large sample of stroke survivors, we used a data-driven approach using principal components analysis of lesion-symptom mapping to identify brain regions crucial for performance on clusters of behavioral tasks without a priori separation into task types. Distinct anatomical boundaries were revealed between a dorsal frontoparietal stream and a ventral temporal-frontal stream associated with separate components. Collapsing over the tasks primarily supported by these streams, we characterize the dorsal stream as a form-to-articulation pathway and the ventral stream as a form-to-meaning pathway. This characterization of the division in the data reflects both the overlap between tasks supported by the two streams as well as the observation that there is a bias for phonological production tasks supported by the dorsal stream and lexical-semantic comprehension tasks supported by the ventral stream. As such, our findings show a division between two processing routes that underlie human speech processing and provide an empirical foundation for studying potential computational differences that distinguish between the two routes.
关键词：aphasia ; speech production ; speech comprehension ; voxel-based lesion-symptom mapping ; speech processing