The authors reported an anesthetic experience with removal of a pancreas B-cell tumor in a 43 year old man. Thiopental sodium was used for i duction, followed by ether-oxygen supplemented with pancuronium for muscle relaxation. An endotracheal semiclosed circle absorption technique with controlled ventilation was emploged. The patient well tolerated both the anesthesia and surgery but he showed a marked increase of blood glucose level with intermittent administration of 50% glucose solution and ether inhalation.