文章基本信息

标题：Normalization of DNA Microarray Data with BIC Model Comparison
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作者：Takeo Okazaki
期刊名称：International Journal of Computer Science and Network Security
印刷版ISSN：1738-7906
出版年度：2014
卷号：14
期号：3
页码：9-15
出版社：International Journal of Computer Science and Network Security
摘要：DNA microarray data, which are efficient for estimation and identification of genetic network, have a large variety due to those experimental environments and measurement. Standardization by an appropriate bias correction is needed for the comparison and the data integration between two or more experiments. On the grounds of normality of distribution in the ideal expression data, some adjustment methods that consider a specific bias for specific expression data have been proposed. In this research, after all combinations of assumed multiple bias and the adjustment methods were modeled, and the appropriate model by BIC was selected for normalization of expression data. The proposal method was applied to a Yeast, Escherichia coli, and Homo sapiens microarray data from Stanford Microarray Database, and the comparative experiment results with previous methods were shown so far.
关键词：DNA Microarray; Gene Expression Data; Normailization; BIC