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  • 标题:Nilotinib therapy after resistance and intolerance to imatinib in CML patient with trisomy of the chromosome 8
  • 作者:Antonella Russo Rossi
  • 期刊名称:Clinical Management Issues
  • 印刷版ISSN:2283-3137
  • 出版年度:2015
  • 卷号:4
  • 期号:5S
  • 页码:23-27
  • 语种:Italian
  • 出版社:SEEd
  • 摘要:In this article is presented the case of a 30-year-old woman with chronic myeloid leukaemia (CML) treated with imatinib for 15 months, and then with nilotinib as second-line therapy. Two episodes of grade 3 neutropenia, the detection of the trisomy of chromosome 8 and the failed achievement of a major molecular response (MMolR) in 15 months led to the switch to nilotinib. With nilotinib the patient obtained the lack of the genetic anomaly in 3 months and a complete molecular response (CMolR) in 6 months, all confirmed at 9 months. No haematologic or extra-haematologic adverse events were detected with this second-line agent.
  • 关键词:Chronic myeloid leukemia;Nilotinib;Intolerance to imatinib;Neutropenia imatinib-related
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