文章基本信息

标题：RANCANGAN D-OPTIMAL MODEL MICHAELIS MENTEN DAN EMAX DENGAN MATLAB
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作者：Tatik Widiharih ; Sri Haryatmi ; Gunardi Gunardi 等
期刊名称：MEDIA STATISTIKA
印刷版ISSN：1979-3693
电子版ISSN：2477-0647
出版年度：2015
卷号：8
期号：2
页码：69-80
DOI：10.14710/medstat.8.2.69-80
语种：English
出版社：MEDIA STATISTIKA
摘要：Michaelis Menten and Emax models are widely used in chemistry, pharmacokinetics and pharmacodynamics areas. D-optimal criteria is criteria with the purpuse to minimize the variance of the estimator of parameters in the model. In this paper will discuss the D-optimal design for Michaelis Menten and Emax models with homoscedastics error assumtion. Determination of D-optimal designs based on Generalied Equivalence Theorem Kiefer-Wolvowitz. We used minimally supported design with the proportion of each design point is uniform, lower bound of design region is design point and the others are interior points. Keywords: D-optimal, Michaelis Menten, Emax, Minimally Supported Design, Homoscedastics
其他摘要：Michaelis Menten and Emax models are widely used in chemistry, pharmacokinetics and pharmacodynamics areas. D-optimal criteria is criteria with the purpuse to minimize the variance of the estimator of parameters in the model. In this paper will discuss the D-optimal design for Michaelis Menten and Emax models with homoscedastics error assumtion. Determination of D-optimal designs based on Generalied Equivalence Theorem Kiefer-Wolvowitz. We used minimally supported design with the proportion of each design point is uniform, lower bound of design region is design point and the others are interior points. Keywords: D-optimal, Michaelis Menten, Emax, Minimally Supported Design, Homoscedastics