文章基本信息

标题：Effect of vitamin D 3 supplementation on iron status: a randomized, double-blind, placebo-controlled trial among ethnic minorities living in Norway
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作者：Ahmed A. Madar ; Lars C. Stene ; Haakon E. Meyer 等
期刊名称：Nutrition Journal
印刷版ISSN：1475-2891
电子版ISSN：1475-2891
出版年度：2016
卷号：15
期号：1
页码：74
DOI：10.1186/s12937-016-0192-7
语种：English
出版社：BioMed Central
摘要：Background Both vitamin D and iron deficiencies are widespread globally, and a relationship between these deficiencies has been suggested. However, there is a paucity of randomised controlled trials assessing the effect of vitamin D supplementation on iron status. Purpose We aimed to investigate whether 16 weeks of daily vitamin D₃ supplementation had an effect on serum ferritin, haemoglobin, serum iron and transferrin saturation. Methods Overall, 251 participants from South Asia, Middle East and Africa aged 18–50 years who were living in Norway were randomised to receive daily oral supplementation of 10 μg vitamin D₃, 25 μg vitamin D₃, or placebo for 16 weeks during the late winter. Blood samples from baseline and after 16 weeks were analysed for serum 25-hydroxyvitamin D (s-25(OH) D), serum ferritin, haemoglobin and serum iron. In total, 214 eligible participants completed the intervention (86 % of those randomised). Linear regression analysis were used to test the effect of vitamin D3 supplementation combined (10 or 25 μg) and separate doses 10 or 25 μg compared to placebo on change (T2-T1) in each outcome variable adjusted for baseline s-25(OH)D values. Results There was no difference in change in the levels of s-ferritin (1.9 μg/L, 95 % CI: -3.2, 7.0), haemoglobin (-0.02 g/dL, 95 % CI: -0.12, 0.09), s-iron (0.4 μg/L, 95 % CI: -0.5, 1.3) or transferrin saturation (0.7 %, 95 % CI: -0.6.1, 2.0) between those receiving vitamin D₃ or those receiving placebo. Serum 25-hydroxyvitamin D increased from 29 nmol/L at baseline to 49 nmol/L after the intervention, with little change in the placebo group. Conclusions In this population of healthy ethnic minorities from South Asia, the Middle East and Africa who had low vitamin D status, 16 weeks of daily supplementation with 10 or 25 μg of vitamin D₃ did not significantly affect the haemoglobin levels or other markers of iron status.
关键词：Iron status ; Vitamin D ; Immigrants ; Randomised controlled trials