文章基本信息

标题：Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants
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作者：Daniele Mandrioli ; Fiorella Belpoggi ; Ellen K. Silbergeld 等
期刊名称：Environmental Health - a Global Access Science Source
印刷版ISSN：1476-069X
电子版ISSN：1476-069X
出版年度：2016
卷号：15
期号：1
页码：97
DOI：10.1186/s12940-016-0180-6
语种：English
出版社：BioMed Central
摘要：Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.
关键词：Aneuploidy ; Carcinogens ; Reproductive toxicants ; Endocrine disruptors ; Chromosomes ; Early diagnose ; Bioassays ; Risk assessment ; mFISH ; Laser scanning microscopy