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标题：Predictors of Breast Cancer Survival in a Tertiary Care Hospital in Coastal Karnataka
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作者：Nair Suma ; Atreya R Mihir ; Kathrikolly Thejas 等
期刊名称：International Journal of Collaborative Research on Internal Medicine & Public Health
电子版ISSN：1840-4529
出版年度：2016
卷号：8
期号：6
出版社：DRUNPP Sarajevo
摘要：Background and Objectives: Breast cancer survival is sparingly addressed in India due toinadequate follow-up, lack of organized screening activities and an incomplete system of deathregistration. This study analyses the specific factors affecting breast cancer survival in a tertiarycare hospital.Methods: This was a five year retrospective analysis of a cohort of breast cancer patients whoattended a tertiary care hospital in Southern India. Case records of 112 women fulfilling theinclusion criteria were reviewed. SES (socioeconomic status), age at menarche, family history ofbreast cancer, disease staging by TNM (Tumour Node Metastasis) criteria and treatmentmodality were some of the variables considered for estimating the hazard ratio using the Coxregression analysis. Survival probability was analysed using the Kaplan-Meier and forward Waldcox regression.Results: Women in the study were predominantly (68%) from the lower socio economic stratawith more than half (57%) being less than 50 years of age. Seventy two percent of thempresented with a local extension of the disease while 13% had evidence of distant metastasis.Overall mean survival rate was noted to be 53.7 months (95% CI 51.6, 55.9). Stage at diagnosis(distant metastasis) (RR 5.11, 95% CI 1.599 – 16.334, p < 0.05) and age at menarche (< 14years)(RR 2.866, 95% CI (1.175 – 6.990), p < 0.05) were found to have a significant impact on theoutcome. The reported death rate among the study population was 27.7%.Conclusion: This study shows a promising overall 5 year disease survival where stage atdiagnosis was found to be an important predictor. Increasing awareness about early detectioncoupled with an organised screening programme that coordinates with existing treatmentfacilities could go a long way in improving the mortality burden due to breast cancer in thecountry.
关键词：Breast cancer; survival rates; stage at diagnosis