文章基本信息

标题：Synthesis, characterization and antimicrobial activity of novel benzophenone derived 1,2,3-triazoles
本地全文：下载
作者：Fichtali I. ; Laaboudi W. ; El Hadrami E. M. 等
期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2016
卷号：7
期号：5
页码：1633-1641
出版社：University of Mohammed Premier Oujda
摘要：A series of new benzophenone derived from 1,2,3 - triazoles 3a - j was synthesized , in good yields, using Copper - Catalyzed Alkyne - Azide Cycloaddition (CuAAC) reaction between a variety of commercial and synthesized alkynes and 4 - (azidomethyl)benzophenone. The structure of synthesized compounds were confirmed by spectral techniques 1 H NMR, 13 C NMR, and high - re so lution mass spectrometry (HRMS). The prepared compounds were also tested in vitro for their antibacterial activity against Gram - positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram - negative bacteria ( Escherichia coli ), and fungi ( Candida albicans ). Among the synthesized compounds 3a and 3b showed an interesting antimicrobial activity against all the tested strains except E. coli which showed a slightly resistance.
关键词：antimicrobial activity ; ; ; benzophenone ; ; carbohydrates; ; cycloaddition ; ; 1;2;3 ; ; ; triazole