Psychosocial risks are widely recognised as major challenges to occupational health and safety. The risk management approach, which starts with an assessment of the risk that they pose, is acknowledged as the most effective way of preventing and managing psychosocial risks at the workplace. This paper presents the findings and action taken following a risk assessment of psychosocial risks, at the World health Organization Regional Office for the Eastern Mediterranean (EMRO) and country offices, carried out on behalf of the Committee on Health and Safety in the Workplace in EMRO. The findings show that psychosocial risks pose a threat to the mental well-being of staff. Management and co-worker support, rewards, possibilities for development, and trust mitigate the negative impact of psychosocial risks. The results of this risk assessment are being used to develop interventions aimed at enhancing the sense of well-being of staff, initially through actions at the employee level.