文章基本信息

标题：The need to accelerate access to new drugs for multidrug-resistant tuberculosis
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作者：Helen S Cox ; Jennifer J Furin ; Carole D Mitnick 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：2015
卷号：93
期号：7
页码：491-497
DOI：10.2471/BLT.14.138925
出版社：World Health Organisation
摘要：Approximately half a million people are thought to develop multidrug-resistant tuberculosis annually. Barely 20% of these people currently receive recommended treatment and only about 10% are successfully treated. Poor access to treatment is probably driving the current epidemic, via ongoing transmission. Treatment scale-up is hampered by current treatment regimens, which are lengthy, expensive, poorly tolerated and difficult to administer in the settings where most patients reside. Although new drugs provide an opportunity to improve treatment regimens, current and planned clinical trials hold little promise for developing regimens that will facilitate prompt treatment scale -up. In this article we argue that clinical trials, while necessary, should be complemented by timely, large-scale, operational research that will provide programmatic data on the use of new drugs and regimens while simultaneously improving access to life -saving treatment. Perceived risks – such as the rapid development of resistance to new drugs – need to be balanced against the high levels of mortality and transmission that will otherwise persist. Doubling access to treatment and increasing treatment success could save approximately a million lives over the next decade.