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标题：TNF- α and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation
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作者：Valentina Carito ; Stefania Ciafrè ; Luigi Tarani 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2015
卷号：51
期号：4
页码：382-386
DOI：10.4415/ANN_15_04_21
出版社：Editrice Kurtis Srl
摘要：Background. Polyphenols from olive are known to possess antioxidant and anti-inflam- matory properties. Aim. The aim of this study was to study whether or not 10 consecutive days i.p. admin- istration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF- α and IL-10. Materials and methods. Inflammation was induced in the mouse paw by 2 carrageenan injections (50 μl vol, 5 mg/kg each). TNF- α and IL-10 were measured by enzyme-linked immunosorbent assay. Results. Carrageenan decreased IL-10 in the paws, however, this reduction appeared to be less evident in mice treated with carrageenan but administered with polyphenols. As for TNF- α , our findings did not reveal differences between groups but an increase in the polyphenol and carrageenan group if compared to the carrageenan only group. As for antioxidant polyphenols' properties, no differences between groups in the serum glutathione were found. Conclusions. Altogether, this investigation shows that olive polyphenols in the mouse may modulate the levels of cytokines having a role in the process of inflammation as TNF- α and IL-10.
关键词：polyphenol; olive; inflammation