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标题：Formulation and evaluation of mucoadhesive buccal films of Diclofenac Sodium
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作者：J. Balasubramanian ; N. Narayanan ; M. Senthil Kumar 等
期刊名称：Indian Journal of Innovations and Developments
印刷版ISSN：2277-5382
电子版ISSN：2277-5390
出版年度：2012
卷号：1
期号：2
页码：68-73
出版社：Indian Society for Education and Environment
摘要：Buccal drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. A buccal film for systemic administration of diclofenac sodium has been developed using hydroxyl propyl methylcellulose, poly vinyl pyrolidone, glycerin, eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, in- vitro adhesion, drug release, weight variation, folding endurance, etc. The in vitro release studies were conducted for diclofenac sodium patches in phosphate buffer-pH-6.6 solution. The mechanism of release is diffusion process followed by first order kinetics. The formulated patches exhibit drug release in the range of 76.92 to 92.12% in four hours.
关键词：Mucoadhesive Film, Diclofenac Sodium, First Order Kinetics, in- vitro Release